Salt-sensitive hypertension (SSH) has a high prevalence and a low treatment rate, and Chrysanthemum is a typical medicinal herb that is also used as a food. To investigate the therapeutic effects of Chrysanthemum on salt-sensitive hypertension, this study used network pharmacology methods to screen for common targets between Chrysanthemum and SSH, construct a protein-protein interaction network, and perform GO functional analysis, KEGG pathway enrichment analysis, molecular docking, and molecular dynamics simulation. In the animal experiments, Dahl salt-sensitive (SS) rats were used to establish an SSH animal model via a high-salt diet. The rats were treated with Chrysanthemum water extract for 30 days, and blood pressure and body weight were monitored. Network pharmacology identified 26 common targets between Chrysanthemum and SSH, with core targets including prostaglandin-endoperoxide synthase 2 (PTGS2) and inducible nitric oxide synthase (NOS2). GO analysis suggests that Chrysanthemum is primarily involved in biological processes such as steroid metabolism, while KEGG enrichment analysis indicates that it may exert its antihypertensive effects through multiple pathways, including steroid hormone biosynthesis and metabolic pathways. Molecular docking and molecular dynamics simulation further suggested that PTGS2 binds stably and tightly to compounds such as diosmetin. Animal experiments confirmed that Chrysanthemum intervention significantly reduced blood pressure and the urine protein-to-creatinine ratio in SS rats, exhibiting therapeutic effects against salt-sensitive hypertension and providing a theoretical basis for the subsequent application of Chrysanthemum in the management of this condition.