In recent years, the demand for quality control in the fruit and vegetable processing industry has been increasing. Gas chromatography-ion mobility spectrometry, as a fast, practical, and visual analytical tool with stable on-line determination and accurate performance has gradually gained prominence for the detection of volatile organic compounds in the field of fruit and vegetable analysis. In recent years, the application of gas chromatography-ion mobility spectrometry has been widely utilized and studied. On this basis, this paper first briefly summarizes the technical principle, operation process, and analytical method of gas chromatography-ion mobility spectrometry. Thereafter, its specific application in the on-line, dynamic flavor analysis of different fruit and vegetable products is introduced, with emphasis on breakthroughs and the applicability of this technique. This technique is also widely used in identifying the adulteration of fruit and vegetable products, origin traceability, and assessing quality changes during storage. Finally, the challenges, future directions, and opportunities for gas-phase ion mobility spectrometry are discussed.