The Cd and Cr contents of 49 sorghum samples from five regions of Liaoning Province were determined by inductively coupled plasma mass spectrometry (ICP-MS). Based on Monte Carlo simulation, the non-carcinogenic risk index (HQ), total non-carcinogenic risk index (HI), carcinogenic risk index (CR), and total carcinogenic risk index (TCR) of the sorghum samples were evaluated, and guidelines for consumption were provided considering the existing health risks. The Cd and Cr content of the sorghum samples from five regions in Liaoning were in the range of 0.002~0.056 and 0.116~0.782 mg/kg, respectively. For adults, the HQ and HI of sorghum from the five regions were less than 1, whereas the CR and TCR were less than 1×10-4. For children, the HQ and HI of sorghum from the five regions were less than 1, whereas the CR was less than 1×10-4, with the TCR of sorghum from the Shuangta and Tieling regions being less than 1×10-4. However, the TCR for sorghum from the Shenhe, Jianping, and Fumeng regions was 1.04×10-4, 1.16×10-4, and 1.06×10-4, respectively, where the values are slightly larger than 1×10-4. The overall degree of pollution of sorghum samples from the five regions in Liaoning Province was low, with the Cd and Cr levels meeting national standards. The HQ, HI, CR, and TCR of sorghum for adults were at safe levels for all five regions. The HQ, HI, and CR of sorghum from all five regions were at safe levels for children, with only the Shenhe, Jianping, and Fumeng regions having a lower total carcinogenic risk for children. However, the total carcinogenic risk could be minimized when the frequency of exposure in Shenhe, Jianping, and Fumeng was controlled to less than 58, 52, and 57 d/a, respectively.