The modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method, as a pre-treatment method, combined with gas chromatography-tandem mass spectrometry (GC-MS/MS), was established for the determination of seven chiral pyrethroid organic pollutants in eggs, so as to provide a basis for the establishment of the pyrethroid residue limit in eggs. The egg samples were extracted with 80% ethyl acetate-acetone, purified by ethylenediamine-N-propylsilane (PSA), and dehydrated by anhydrous magnesium sulfate. The obtained extracts were further separated using a HP-5MS capillary column. The seven compounds were determined using an electron impact (EI) ion source and multi-reaction monitoring (MRM) mode and quantified using the matrix-matched calibration curve external standard method. The results showed that this method could effectively separate the seven chiral pyrethroids. The seven compounds showed good peak shapes, displayed good linearity over the range of 1~200 μg/L, and the correlation coefficients were greater than 0.99. The limits of detection (LODs) were 0.46~1.59 μg/kg, the limits of quantitation (LOQs) were 1.52~5.29 μg/kg, and the recovery rates were in the range of 72.1%~117.5% with relative standard deviations (RSDs) between 1.6% and 15.1% (n = 6). This pre-treatment method was proven to be simple, accurate, efficient, and suitable for rapid screening and quantitative analysis of chiral pyrethroid organic pollutants in eggs.