College of Pharmacy, Weifang Medical University, Weifang 261053, China) (2. Department of Basic Medicine, Weifang Medical University, Weifang 261053, China) Abstract: The aim of this study was to investigate the effect of aqueous extracts from Cyclocarya paliurus leaves (ACP) on hyperlipidemia, hypercoagulability, fibrinolysis and lipid peroxidation in diabetic nephropathy (DN) rats. High fat and sugar diet and a low dose of STZ were used to induce the DN rat model. Then the animals were divided into five groups: model, metformin, and three doses of ACP（0.05，0.10，0.15 g/kg/day）groups. General status, body weight, blood glucose, urine output and urine protein were recorded after intragastric administration. The indicators of blood fat in serum; blood coagulation and fibrinolysis in plasma and lipid peroxidation in liver were measured. The results showed that the levels of blood glucose, urine protein, TC, TG, LDL-C, FFA, D-Dimer, PTA, MDA were decreased significantly (P<0.05) with the highest decreasing rate of 58.03%, while the levels of HDL-C, PT, APTT, TT, FIB, INR, PT-R, APTT-R, SOD, GSH-Px, CAT, T-AOC were increased significantly (P<0.05) with the highest increasing rate of 74.60%. These indicators were correlated with the level of blood glucose well and FFA in particular(r=0.9990). This research suggested that ACP could regulate lipid metabolism, ameliorate hypercoagulability and the lipid peroxidation in DN rats.