Argopecten irradians was stored at 4 ℃ and 0 ℃ to -1.6 ℃ after pre-treatment with biological preservatives. Possible correlation between biogenic amines and decay index was investigated in terms of sensory quality, total bacteria counts (TBC), total volatile basic nitrogen (T-VBN), K value, and content of seven biogenic amines. The results showed that with the extension of storage time, TBC, T-VBN and K values increased, but thesamples stored at low temperature and treated with preservatives showed slower rates of increase. In addition, low temperatures and biological preservatives prevented the production of seven kinds of biogenic amines. In these samples, the inhibitory effect on putrescine and cadaverine was significant (p < 0.05), while that on the remaining five kinds of biogenic amines was not significant (p > 0.05). Variations in putrescine and cadaverine were the most significant in Argopecten irradians stored under chilled conditions. Moreover, putrescine and cadaverine significantly correlated with other evaluation indicators at the 0.05 significance level. Cadaverine and putrescine were indicators of the spoilage process, and therefore, can be used as quality indicators for Argopecten irradians.