Peptide chelated zinc is a new organic metal compound with various bioactivities. It is mainly prepared by three methods, including synthesis with zn2+ and artificial peptide, synthesis of zn2+ and natural peptide by enzymolysis of plant and animal protein, and extraction from plant and animal tissue. Due to the difference of peptide ligands, the peptide chelated zinc showed varied structure and bioactivities including antibacterial and bacteriostasis effect, regulations of physiological functions and immune, and antioxidation.. The recent researches of bioactivities and safety of peptide chelated zinc were reviewed in this research. Suggestion were proposed on more investigation of elative toxicology and applying safety of this compound, to promote the potential industrial application of peptide chelated zinc