Essential oil was extracted from Tussilago Farfarae L. by the methods of simultaneous distillation extraction (SDE) and supercritical fluid extraction (SFE). The main chemical components of essential oils were determined by GC-MS and the similarities and differences between them were compared in this study. The results indicated that the yield of essential oil by SFE was higher than that by SDE. And the essential oil by SDE contained plenty volatile components with lower molecular weight, such as β-disabolene, cedrene oxide. Besides these volatile molecules, the essential oil by SFE contained some other characteristic components with higher molecular weight, such as tussilagone, faradiol and so on. The differences between these components of essential oils were caused by the function and characteristics of these two different extraction methods. All these suggested that it was important for the improvement of industrial extraction technology of essential oil.