Fourier transform infrared spectrometry(FT-IR) and nuclear magnetic resonance hydrogen spectrum (1H-NMR) were used for quality control of a chinese traditional patent medicine, Banlangen granules. The main components and sucrose content of Banlangen granules were studied by FTIR spectroscopy. Results showed that alcohol extraction of Banlangen granules can effectively reduce the interference from sucrose on IR characters of Banlangen granules, which was more suitable for the further characterization of Banlangen granules than H2O extraction. Obvious differences in the sucrose content were found in Banlangen granules from different manufactures. This research provided a direct and effective technique for examining the quality of Banlangen granules.